Interaction of human organic anion transporters
Organic anion transporters (oats) are important in the renal secretion, and thus, the clearance, of many drugs and their functional change can result in. Current studies determined the effects of pretreatment with rifampicin, an organic anion-transporting polypeptide (oatp) inhibitor, and the tyrosine kinase inhibitor dasatinib on oatp1b1- and oatp1b3-mediated transport, and to evaluate the oatp-mediated drug-drug interaction (ddi) potential of dasatinib using the static r-value and dynamic. Translations in context of anion in english-dutch from reverso context: drugs which inhibit organic anion transporting polypeptides (oatp) the extent of interaction with potent oatp inhibitors (e g some statins, proteinase.
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxicthe encoded protein is an integral membrane protein and appears to be. Hepatic organic anion transporters oatp1b1 and oatp1b3 are expressed at the sinusoidal membrane of hepatocytes and contribute to the hepatic uptake of a wide variety of clinically used drugs to identify the antibiotics that interact with the human organic anion transporters oatp1b1 and oatp1b3, we. Protein-based drug transporters are found in most tissues including liver, kidney, intestine, and brain because of their complexity and genetic heterogeneity, these proteins are often produced as recombinant membrane.
Figure 1 phylogenetic tree analysis of transporters of the slc22a family the alignment program clustal w ( ) and the phylogenetic tree. Interaction of ethambutol with human organic cation transporters (slc22 family) indicates potential for drug-drug interactions during antituberculosis therapy. Abstract abstract renal excretion of organic anions and cations is mediated by the organic ion transporter family (slc22a) in this study, the mrna levels of the organic ion transporters were quantified by real-time pcr in normal parts of renal tissues from seven nephrectomized patients with renal cell carcinoma, and the distributions and. Recent advances in molecular biology have identified three organic anion transporter families: the organic anion transporter (oat) family encoded by slc22a, the organic anion transporting peptide (oatp) family encoded by slc21a (slco), and the multidrug resistance-associated protein (mrp) family encoded by abcc. The interactions of herbal compounds with human organic anion/cation transporters xiaoxi lu1, ting chan1, chenghao xu 1, for instance, the drug-drug interaction.
Recent investigations involving intact rabbit renal proximal tubules indicated that organic anion transporter 3 (oat3) may be involved in the transport of 2,3-dimercapto-1-propanesulfonic acid (dmps. Interaction of human organic anion transporter polypeptides 1b1 and 1b3 with antineoplastic compounds organic anion transporters,. 1 j pharmacol sci 2010113(2):192-6 epub 2010 may 28 interactions of human organic anion transporters with aristolochic acids babu e(1), takeda m, nishida r, noshiro-kofuji r, yoshida m, ueda s, fukutomi t, anzai n, endou h. Interaction of immunosuppressive drugs with human organic anion transporter (oat) basolateral organic anion transporters we studied the interaction of 12. Organic anion transport polypeptide c an organic anion transporter found in human liver it is capable of transporting a variety organic anions and mediates sodium-independent uptake of bile in the liver.
Membrane transporters play critical roles in moving a myriad of endogenous and exogenous substances across cellular and organelle membranes, including the major nutrient metabolites sugars, digested peptides, amino acids and nucleosides, rare elements such as hormones and neurotransmitters, and xenobiotics. Since the substrate specificities of oatp1b1, 1b3, and 2b1 are broad and overlapping, the contribution of each isoform to the overall hepatic uptake is of concern when assessing transporter-mediated drug–drug interactions (ddis) or genetic polymorphism impact in the clinic. Nucleoside reverse transcriptase inhibitors (nrtis) need to enter cells to act against the hiv-1 human organic cation transporters (hoct1–3) are expressed and active in cd4+ t cells, the main target of hiv-1, and have been associated with antiviral uptake in different tissues. The human organic anion and cation transporters are classified within two slc superfamilies superfamily slco (formerly slc21a) consists of organic anion transporting polypeptides (oatps), while the organic anion transporters (oats) and the organic cation transporters (octs) are classified in the slc22a superfamily.
Pharmaceutics 2011, 3 682 figure 1 uptake and export transporters involved in the intestinal absorption (enterocyte) and the hepatic (hepatocyte) and renal (renal epithelium) excretion of oral antidiabetic. Read interactions of human organic anion as well as cation transporters with indoxyl sulfate, european journal of pharmacology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at. Imagine a global collaborative knowledge base interaction of human organic anion transporters 2 and 4 with human organic anion transporters mediate the.
Médicaments inhibiteurs des transporteurs des anions organiques (oatp) les conséquences de l'interaction avec les inhibiteurs des transporteurs des anions organiques (oatp) puissants (tels que certaines statines, inhibiteurs de la protéinase, antituberculeux) reste non évaluée. Introduction it has long been established that an important function of the kidney and liver is the secretion of organic anions into the urine and bile, respectively, and it has been recognized that such secretion is an active and saturable process that can be modulated by competitive inhibitors. Interaction potential of anionic competitive inhibition of human organic anion transporters 1 (slc22a6) and 3 (slc22a8) by major components of the medicinal. The organic anion transporter 1 (oat1) also known as solute carrier family 22 member 6 (slc22a6) is a protein that in humans is encoded by the slc22a6 gene it is a member of the organic anion transporter (oat) family of proteins.
Abstract organic anion transporter 2 (oat2 [slc22a7]) is a multispecific organic anion transporteralthough several substrates of human oat2 (hoat2) have been elucidated, a possible involvement of hoat2 in drug interaction is less defined. Obstructive jaundice occurs in patients suffering from cholelithiasis and from neoplasms affecting the pancreas and the common bile duct the absorption, distribution and elimination of drugs are impaired during this pathology prolonged cholestasis may alter both liver and kidney function lactam. 2018 transporters conference postponed the transporters in drug discovery and development conference scheduled for july 30-aug 1, 2018 at the university of rhode island college of pharmacy, has been postponed due to unforeseen circumstances.